Charlie Austin was the Saint that turned to a sinner from a Burnley perspective as the striker haunted his former club with two goals in his side's 3-1 win at the St Mary's Stadium.
The 27-year-old frontman, who has now scored seven times for Southampton in all competitions this term, netted twice as the Clarets lost their way in the second half following a goal-less first half.
Goalkeeper Tom Heaton, though, won't have done his England hopes any harm with a string of first half saves that kept the home side at bay.
The Clarets skipper displayed his international credentials as early as the fifth minute with an unbelievable stop to deny Austin.
The former Turf Moor favourite, who scored 45 goals during his time with the club, did well to steal a yard ahead of Ben Mee to meet Matt Target's cross only for Heaton to plunge to his left and claw the ball off the line.
The 30-year-old's next involvement was slightly more straight forward as he denied Dusan Tadic once Nathan Redmond's initial effort had been blocked.
After the early onslaught, which was broken up when Sam Vokes hooked Stephen Ward's delivery wide of the near post, the away side started to get more of a hold in the game.
However, Heaton was still called upon to keep the scores level. The visitors' high line was exposed when Dusan Tadic got in behind from Fraser Forster's clearance but the Serbian failed to flick the ball beyond the former Manchester United trainee.
The talking point of the first half arrived just after the half-hour when Johann Berg Gudmundsson was sent tumbling inside the area by Virgil Van Dijk.
Though replays suggested that the Clarets should've been awarded a spot kick, referee Mike Dean didn't even take a second look as he waved away appeals.
And, as another high ball once again caught Sean Dyche's side out, Austin struggled to get the ball from underneath his feet as he tamely side-footed his effort wide.
Despite numerous call ups to the Three Lions set up, Heaton has only featured for his country for a couple of minutes. But interim boss Gareth Southgate will have taken note of the keeper's performance in the opening 45 minutes.
Heaton was well positioned at his near post to beat Nathan Redmond's fierce drive away after the tricky winger twisted and turned inside the box to find a route beyond Dean Marney.
There was a similar outcome when the former Norwich City wide man did well to craft space inside the box moments later as Heaton beat the attempt away before Austin squandered the rebound.
In the closing stages of the half, Van Dijk tried his luck from distance but failed to trouble Heaton.
It was so far so good for the away side, but they were cut deeply early in the second half.
Dyche alluded to "four minutes of madness" that cost the Clarets when they lost to Leicester City at the King Power Stadium last month.
And they suffered something similar against the Saints. Austin opened the scoring within seven minutes of the restart, poking the ball over the line from close range after Van Dijk helped on Tadic's corner.
The hosts then doubled the lead on the hour after Heaton had again foiled Tadic, flicking the midfielder's effort on the turn over the bar.
Steven Davis's resulting corner travelled all the way through to an unmarked Redmond who finally had the beating of Heaton with a rasping right-footed volley.
As the heavens opened in Southampton, so did the floodgates. Southampton made it 3-0 in the 66th minute and it was Austin's third goal in as many appearances against his one-time employers.
Saints substitute Sam McQueen went down in the box under the challenge of Gudmundsson and Austin stroked the ball home from the spot, sending Heaton the wrong way in the process.
The visitors were given a route back in to the game when Tadic was penalised for a foul on Ben Mee from substitute Michael Kightly's set-piece.
Dean pointed to the spot, Vokes stepped up and the Welshman slid the penalty down the middle to make it 3-1.
Davis, Jose Fonte and Jay Rodriguez all went close to extending Southampton's lead in the closing stages but they failed to convert their openings.
For Burnley, it was a third Premier League defeat on their travels.