When the two sides last met, back in mid-January, it was the Hammers who came out on top, with Michail Antonio's early finish proving decisive.
As things stand, the Clarets are 14th in the table, nine points clear of Fulham in 18th with just 15 points left to play for. The Clarets gave themselves a little bit of breathing space from the bottom three following a fantastic 4-0 win over Wolves at Molineux.
Striker Chris Wood was the man of the moment when netting a first half hat-trick, which saw him usurp Ashley Barnes as the club's all-time top Premier League goalscorer with 43.
The New Zealander, who has netted six times for the Clarets against West Ham in the top flight, has now hit double figures in four successive seasons at this level, a record only matched by Harry Kane, Mohamed Salah, Jamie Vardy, Heung-Min Son and Alexandre Lacazette.
Dyche said: "Striker is the hardest role on the pitch, I used to be a centre half and I made sure it was difficult for them, trust me!
"I've never really over-questioned centre forwards because of the respect I have for the position.
"Woody is still improving his hold up play and some of the simpler things - not simple, important but simple things - keeping the ball for the team...
"But he finds a way of scoring goals, and coaches and managers marvel at that."
Here are today's biggest transfer stories and the latest team news involving Burnley and the rest of the Premier League, as the reaction to the midweek action continues: