The full-time whistle at Molineux sparked angry protests as a large section of the Wolves support vented their frustration and impatience at club chairman Steve Morgan after a tumultuous campaign.
"You're sending us down" were the chants from the Jack Harris Stand as goals from Danny Ings and Martin Paterson sent Dean Saunders's side plummeting towards League One.
Wins for both Barnsley and Huddersfield Town means Wolves are now three points adrift of safety ahead of their trip to Brighton on the final day of the season as the club continues to experience a hangover from the departure of former boss Mick McCarthy. Their 2-1 defeat means they could be the first club since Swindon to endure back-to-back relegations from the Premier League and the first club to suffer that fate on two separate occasions in their history.
In contrast the Clarets secured their Championship survival in comfortable fashion despite having defender Michael Duff dismissed for a second bookable offence in the second half after tripping Wolves skipper Kevin Doyle on the edge of the box.
In a hectic first half midfielder Tongo Doumbia was the first player of the afternoon to hit the target as he caught Lee Grant out of position from distance but the Clarets stopper recovered to save low to his left.
The hosts were utilising the flanks well, pummelling the penalty area with crosses, and as they continued to press Kieran Trippier was forced to head wide when under pressure from Stephen Hunt at the back post.
But the Clarets weathered the pressure well and looked dangerous on the break. Moments after Chris McCann's effort following a short corner was deflected wide, the Clarets took the lead in the seventh minute when Trippier touched the ball in to Ings and the striker swivelled instinctively to bend the ball left-footed beyond Dorus De Vries - his first goal since the 2-0 win at Millwall and only his third of the term.
The visitors knocked the ball about confidently, playing with freedom and without fear, and in the next attack Dean Marney headed over from deep inside the area from Danny Lafferty's whipped centre.
Sean Dyche's men were denied a second midway through the half courtesy of a stunning stop from De Vries to deny former Wolves striker Sam Vokes's close range effort before Roger Johnson hooked clear as Ings smashed the ball back across goal from the follow up.
The first half saw the home side craft eight corners and from one, defender Kaspars Gorkss had the crowd on their feet as he rose to meet Bjorn Sigurdarson's set-piece, but his header darted in to the side-netting and was met by gasps of disbelief.
The best move of the opening 45 minutes arrived when Stephen Ward's clever flick in to Sigurdarson took Trippier out of the game and as the pair traded passes Ward's cross was spilled by Grant before Duff denied Sigurdarson from turning the loose ball home after Doyle's initial shot was blocked.
Then, as the half came to a close, Lafferty cleared Doyle's header from underneath the crossbar.
For a club that has shelled out more than £10m. on improving the squad for a promotion push, Wolves never looked like a side with the quality to match those riches. Their performance was impoverished, desperate and crudely uninspiring.
And the Clarets punished the hosts early in the second half when Ings fired the ball in to the box, Vokes flicked the ball toward the six-yard box and Paterson hammered the ball past De Vries from close range to double the advantage and prompt a chorus of boos from within the four stands of the stadium.
Vokes could have added insult to injury as he returned to his former stomping crowd but after taking the ball past Gorkss inside the area his effort clipped the top of the bar.
There was little imagination from the hosts after the break as they were reduced to a long ball approach, a tactic mopped up expertly by captain Jason Shackell and his determined defensive team mates.
Either side of Duff's sending off in the 65th minute, Wolves went close to reducing the deficit as Hunt headed wide at the near post from substitute Bakary Sako's corner while Liam McAlinden, who had replaced Hunt, bent a delightful effort around Grant that dipped agonisingly wide of the far post.
But even after the away side were reduced to 10, Wolves failed to find a sequence of play to trouble their opponents. On the other hand the Clarets were clinical and Paterson's effort whistled just wide of the post after the striker latched on to Ings's crossfield pass and cut inside Matt Doherty from the left.
Karl Henry flashed an effort wide of the upright as the support grew more audible while Doumbia drilled wide of the target when well placed inside the area after Sako and Jack Robinson combined down the left flank.
Vokes was denied by a last ditch challenge by Gorkss when faced with an empty net after beating De Vries to a loose ball and at the other end Sako's 20-yard effort rose over the crossbar.
Wolves committed men forward in desperation and hope and Grant produced a phenomenal save as he plunged low to his right to turn Robinson's low effort around the post. However, from the resulting corner, Johnson won the aerial battle, Doyle hooked the ball in to the six yard box and Nouha Dicko had the simple task of firing home from close range.
Doyle lifted the ball over the bar on the turn as Wolves sought a point to help their plight but the Clarets were resolute and almost extended their cushion in the final seconds as Ings charged down Doherty, ran the ball from the halfway line but failed to test De Vries with a low effort.
The Clarets now entertain Ipswich Town on the final day of the season, kick-off 12-45 p.m.